ncRNA name | Rho siRNA |
ncRNA Category | siRNA |
Disease name | retinitis pigmentosa (RP) |
Species | Mus musculus |
Tissues/Cell_line | retinas |
Methods | siRNA injection, immunodetection, RT-PCR, Fundus imaging, ERG, OCT, morphology analysis, flow cytometry |
Expression pattern | associated |
Functional description | In this study we demonstrate long-term rescue of retinal structure and function by a single virus expressing both RHO replacement cDNA and small interfering RNA (siRNA) to digest mouse Rho and human P23H RHO mRNA. |
PubMed ID | 22289036 |
Year | 2012 |
Title | Long-term rescue of retinal structure and function by rhodopsin RNA replacement with a single adeno-associated viral vector in P23H RHO transgenic mice. |
Drug-related ncRNA | NO |
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