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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinitis pigmentosa (RP)
ncRNA name Rho siRNA
ncRNA Category siRNA
Disease name retinitis pigmentosa (RP)
Species Mus musculus
Tissues/Cell_line retinas
Methods siRNA injection, immunodetection, RT-PCR, Fundus imaging, ERG, OCT, morphology analysis, flow cytometry
Expression pattern associated
Functional description In this study we demonstrate long-term rescue of retinal structure and function by a single virus expressing both RHO replacement cDNA and small interfering RNA (siRNA) to digest mouse Rho and human P23H RHO mRNA.
PubMed ID 22289036
Year 2012
Title Long-term rescue of retinal structure and function by rhodopsin RNA replacement with a single adeno-associated viral vector in P23H RHO transgenic mice.
Drug-related ncRNA NO

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